Setting PAH treatment goals and expectations
When you decide to start your pediatric patient on treatment with UPTRAVI, it's important to set goals and expectations with them and their caregivers.
Before starting UPTRAVI, remind them of the following:
- Anticipate a call from the specialty pharmacy to alert them of their next shipment of UPTRAVI
- Patients should not change the dose or stop taking UPTRAVI unless their doctor tells them to do so1
- Understand expectations for potential side effects. Patients and their caregivers should follow up with their doctor if the child has side effects that cannot be tolerated1
- Try to take UPTRAVI with food. This may help children tolerate the dose better if there are any side effects with UPTRAVI1
- After the dose adjustment phase, the child will have found their personal maintenance dose of UPTRAVI. This will be the dose the child continues to take on a regular basis, unless their doctor tells them otherwise1
UPTRAVI pediatric dosing regimen*
100 mcgLight Yellow
100 mcgLight Yellow
800 mcgGreen
150 mcgRed
150 mcgRed
1200 mcgDark violet
150 mcgRed
150 mcgRed
1600 mcgBrown
200 mcgLight yellow
200 mcgLight yellow
1600 mcgBrown
*Actual regimen may vary depending on patients dosage and ability to swallow whole tablets.
**Once daily for pediatric patients with moderate hepatic impairment (Child-Pugh class B) and co-administration with moderate CYP2C8 inhibitors (eg, clopidogrel, deferasirox, and teriflunomide).
100 mcg | 3 mm 150 mcg | 3 mm 200 mcg | 7 mmSize shown in relation to a dime for proportional comparison. Tablet not shown at actual size. Tolerability may
be improved when taken with food.
*Actual regimen may vary depending on patients dosage and ability to swallow whole tablets.
**Once daily for pediatric patients with moderate hepatic impairment (Child-Pugh class B) and co-administration with moderate CYP2C8 inhibitors (eg, clopidogrel, deferasirox, and teriflunomide).
- For pediatric patients with a body weight ≥40 kg to <50 kg multiple tablet dose strengths may be needed to reach the doses up to 1,600 mcg twice daily.
- Re-evaluate further dose titration based on changes in body weight category over time.
- Tolerability may be improved when taken
with food - Swallow the UPTRAVI tablets whole. Do not split or crush the tablets.
The UPTRAVI Dose Adjustment Phase helps meet individual pediatric patient needs1
For pediatric patients, the recommended starting dose of UPTRAVI is determined based on the patient's body weight and is given twice daily.
Alternate methods of administration for patients who cannot swallow tablets whole
Apple or orange juice
UPTRAVI 100 mcg or 150 mcg film-coated tablets can be dispersed and administered in apple or orange juice. Do not disperse the tablet(s) in water or milk.
- Do not crush or split the tablet(s)
- At least 1 mL of juice per tablet is recommended
- Add the juice to the required number of tablet(s) per dosing schedule
- Wait for 5 minutes and then stir until the tablets are dispersed
- Administer the mixture immediately after dispersion
- Do not store tablets that are mixed with juice for later use
Soft foods
Alternatively, UPTRAVI 100 mcg and 150 mcg tablets can also be administered with soft foods such as yogurt, applesauce, or mashed banana.
- Cover the required number of tablets with soft food.
- Administer the mixture immediately
- To ensure no tablet residue is left, add more soft food and administer the contents immediately
- Do not store tablets that are mixed with soft food for later use
